![]() PH 12 was well-tolerated in both laboratory and field studies. ![]() PH 12 was significantly better than HG Plus in preventing heartworm disease in the field study ( P = 0.0367). All four dogs treated with HG Plus that subsequently tested positive for HWs during the field study were from the lower Mississippi River Valley region, where HW resistance to macrocyclic lactone preventives has been confirmed to occur. In the field study, all dogs treated with PH 12 tested negative for adult HW infection on all test days (Days, 365, 480 and 605), whereas four dogs receiving HG Plus (positive control) tested positive for HWs during the study (three dogs on Day 365 and one dog on Day 480). In the laboratory studies, no PH 12-treated dogs had any adult HWs, whereas all control dogs in both studies had adult HWs. PH 12 was 100% effective in preventing HW disease in all three of these studies. Efficacy was determined on Days 365, 480 and 605 using adult HW antigen and microfilaria testing to assess adult HW infection. The field efficacy study included dogs ≥ 10 months of age from 19 veterinary clinics in the USA treated with either 20 monthly doses of Heartgard® Plus (HG Plus) (296 dogs) or two doses of PH 12 (297 dogs) on Days 0 and 365. All dogs were necropsied ~ 5 months post-inoculation for adult worm counts. immitis third-stage larvae (L 3) on Day 365. In each of two laboratory studies, 20 dogs ≥ 12 months of age were randomly allocated to receive a subcutaneous injection of saline or PH 12 on Day 0 and were then inoculated with 50 D. To help prevent heartworm infection in your dog, ask your vet about heartworm prevention and make sure to have your dog tested at least annually.The efficacy of an extended-release injectable moxidectin (0.5 mg/kg) suspension (ProHeart® 12) (PH 12) in preventing the development of Dirofilaria immitis in dogs for 12 months was investigated in laboratory and field studies in the USA. Treatment for heartworm infection often involves several steps. As the worms spread, symptoms may include a persistent cough, problems with exercise, fatigue, and a lower appetite. In many cases, your dog won’t have any symptoms at first. If you suspect your dog has been infected, it’s important to talk to your vet as soon as possible. Talk to your vet about the best combination medication to target the parasites where you live. Targeted Parasites: Many canine heartworm medications are combined with other ingredients that treat various types of fleas and ticks.This will kill any immature heartworms (called microfilariae) in your dog’s system before they can mature. Frequency: How often do you have to administer the medication? To be effective, heartworm medication must be administered regularly.Choose the one that works best for your situation. Administration Route: Heartworm medications are typically available as a tasty chew, but there are also tablets and topical solutions.Most brands of medications come in different colored boxes for different weights. Your vet will help you pick the right one. Your Dog’s Weight: Heartworm preventatives are sold based on your dog’s weight.Things to consider when shopping for dog heartworm medication include: Talk to your vet about heartworm prevention for your dog. Once your dog is infected, they will require veterinary care to treat the infection and prevent serious disease and even death. Without treatment, the worms will mature into adults and potentially infest your dog’s heart, lungs, and blood vessels. ![]() ![]() If an infected mosquito bites your dog, it can pass along heartworm larvae. Heartworms are a type of parasite that are transmitted to dogs through mosquito bites. ![]()
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